A polygon without self-intersections is called lattice if all its vertices have integer coordinates in some 2D grid. Pick's theorem provides a way to compute the area of this polygon through the number of vertices that are lying on the boundary and the number of vertices that lie strictly inside the polygon.
Given a certain lattice polygon with non-zero area.
We denote its area by $S$, the number of points with integer coordinates lying strictly inside the polygon by $I$ and the number of points lying on polygon sides by $B$.
Then, the Pick's formula states:
In particular, if the values of $I$ and $B$ for a polygon are given, the area can be calculated in $O(1)$ without even knowing the vertices.
This formula was discovered and proven by Austrian mathematician Georg Alexander Pick in 1899.
The proof is carried out in many stages: from simple polygons to arbitrary ones:
A single square: $S=1, I=0, B=4$, which satisfies the formula.
An arbitrary non-degenerate rectangle with sides parallel to coordinate axes: Assume $a$ and $b$ be the length of the sides of rectangle. Then, $S=ab, I=(a-1)(b-1), B=2(a+b)$. On substituting, we see that formula is true.
A right angle with legs parallel to the axes: To prove this, note that any such triangle can be obtained by cutting off a rectangle by a diagonal. Denoting the number of integral points lying on diagonal by $c$, it can be shown that Pick's formula holds for this triangle regardless of $c$.
An arbitrary triangle: Note that any such triangle can be turned into a rectangle by attaching it to sides of right-angled triangles with legs parallel to the axes (you will not need more than 3 such triangles). From here, we can get correct formula for any triangle.
An arbitrary polygon: To prove this, triangulate it, ie, divide into triangles with integral coordinates. Further, it is possible to prove that Pick's theorem retains its validity when a polygon is added to a triangle. Thus, we have proven Pick's formula for arbitrary polygon.
Unfortunately, this simple and beautiful formula cannot be generalized to higher dimensions.
John Reeve demonstrated this by proposing a tetrahedron (Reeve tetrahedron) with following vertices in 1957:
$$A=(0,0,0), B=(1,0,0), C=(0,1,0), D=(1,1,k),$$
where $k$ can be any natural number. Then for any $k$, the tetrahedron $ABCD$ does not contain integer point inside it and has only $4$ points on its borders, $A, B, C, D$. Thus, the volume and surface area may vary in spite of unchanged number of points within and on boundary. Therefore, Pick's theorem doesn't allow generalizations.
However, higher dimensions still has a generalization using Ehrhart polynomials but they are quite complex and depends not only on points inside but also on the boundary of polytype.
A few simple examples and a simple proof of Pick's theorem can be found here.